AN EFFICIENT ONE-POT SYNTHESIS OF COUMARIN-PYRROLE HYBRID COMPOUNDS UNDER ENVIRONMENTALLY HARMLESS CONDITIONS

ABSTRACT Coumarin and pyrrole heterocyclics have found to show diversified biological activities. Due to their easy availability and stability they applied in various branches of science. Based on this point of view coumarin-pyrrole hybrid compounds have been synthesized in a one-pot three-component method. Ammonium acetate (NH4OAc) has been found to be an efficient regent and catalyst for this method of synthesis under purely eco-friendly conditions. We have successfully demonstrated the triple role of ammonium acetate as a catalyst, reagent and reaction media. All the synthesized compounds are characterized by analytical and spectral analysis. KEYWORDS: Coumarins, pyrroles, Ammonium Acetate, One-pot synthesis, Solvent less synthesis