Triethanolammonium acetate (teahoac) as a recyclable promoter and medium for green and four-component synthesis of polyfunctionalized pyrrole derivatives

Multi-component synthesis of functionalized pyrrole derivatives was achieved via a fourcomponent condensation reaction of ethyl acetoacetate/ methyl acetoacetate, aromatic amines, nitromethane, and aromatic aldehydes using triethanolammonium acetate (TEAHOAc) ionic liquid as a green solvent and catalyst. Easy access to highly substituted pyrroles, reusability of the catalyst, broad substrate scopes, no column chromatography, short reaction time, good yields of products and solventfree conditions make this protocol environmentally friendly and practically attractive. © 2021 Bentham Science Publishers