Condition of the liver's liver of rats, received a high-fat diet: biochemical indicators

Vasyuk V. L., Levitsky A. P. Condition of the liver’s liver of rats, received a high-fat diet: biochemical indicators. Journal of Education, Health and Sport. 2017;7(1):673-683. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1461947 http://ojs.ukw.edu.pl/index.php/johs/article/view/6182 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 27.03.2017. Revised 28.03.2017. Accepted: 27.01.2017. Condition of the liver’s liver of rats, received a high-fat diet: biochemical indicators V. L. Vasyuk1, A. P. Levitsky2 1 Bukovinian State Medical University 2State Establishment “The Institute of Stomatology and Maxillo-facial Surgery NAMS of Ukraine” Abstract Aim: To determine the liver condition of rats fed with fats of different fatty acid compositions Materials and methods: We used the following dietary fats: refined sunflower oil, refined olive oil, palm oil, milk fat (butter). Feeding of rats was carried out for 41 days using 15 % of the studied oils in the food. The liver condition was evaluated by biochemical markers of liver (elastase, MDA, alkaline phosphatase (ALP), lysozyme, catalase) and blood serum markers (glucose, cholesterol, elastase, ALT, ALP). Results: The increase in the weight gain was more pronounced when feeding with palm oil; the increase of inflammatory markers levels (MDA and elastase) was greater when feeding with palm oil and butter. Conversely, the lysozyme activity in the liver was significantly reduced at fat feeding, particularly for palm oil and butter. In the serum of all animals fed with fat there was the significant increase of glucose and cholesterol levels, as well as the increase of the elastase activity (after palm oil). Conclusion: A high-fat diet causes the development of an initial phase of inflammatory and degenerative processes in liver, which is more pronounced for fats high in palmitinic acid (palm oil and butter). Keywords: fatty food fatty acids, liver, inflammation