Fig. 1 in Potential role of two cytochrome P450s obtained from Lithospermum erythrorhizon in catalyzing the oxidation of geranylhydroquinone during Shikonin biosynthesis

Fig. 1. The proposed biosynthetic pathway of shikonin in L. erythrorhizon. Single arrows represent one step reaction, while double arrows represent multiple step reactions. Dashed arrows signify undefined steps or the enzymes have not been verified yet. The steps with red-colored enzymes indicate the oxidation reactions of converting GHQ to GHQ-3″-OH or GHQ-3″-COOH by CYP76B100 and CYP76B101. PGT, geranyl diphosphate: 4-hydroxybenzoate 3-geranyltransferase; GBA, 3- geranyl-4-hydroxybenzoic acid; GHQ, geranylhydroquinone; GHQ-3″-OH, 3″-hydroxy-geranylhydroquinone; GHQ-3″-CHO, 3″-aldehyde-geranylhydroquinone; GHQ- 3″-COOH, 3″-carboxyl-geranylhydroquinone.Published as part of Song, Wan, Zhuang, Yibin & Liu, Tao, 2020, Potential role of two cytochrome P450s obtained from Lithospermum erythrorhizon in catalyzing the oxidation of geranylhydroquinone during Shikonin biosynthesis, pp. 1-9 in Phytochemistry (112375) 175 on page 2, DOI: 10.1016/j.phytochem.2020.112375, http://zenodo.org/record/829528