Fig. 9. (A) Inhibitory effects of 15 on the accumulation of rhodamin-123 (Rho-123) in HepG2/DOX. (B) Inhibitory effects of 15 on the efflux of Rho-123 in HepG2/ DOX. Scale bar = 200 μm.Published as part of Shaker, Sharpkate, Sang, Jun, Yan, Xue-Long, Fan, Run-Zhu, Tang, Gui-Hua, Xu, You-Kai & Yin, Sheng, 2020, Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells, pp. 1-12 in Phytochemistry (112395) 176 on page 9, DOI: 10.1016/j.phytochem.2020.112395, http://zenodo.org/record/829566
Fig. 2. Key HMBC correlations of Compounds 1, 5 and 9.Published as part of Du, Kaicheng, Yang, Xinyo...
Fig. 5. Cytotoxic activities of transformed E. lathyris root extract in human carcinoma and embryoni...
Fig. 3. 1H–1H COSY and key HMBC (A) and ROESY (B) correlations of 3.Published as part of Wang, Siyi,...
Fig. 8. Effects of 15 on the expression of P-gp.Published as part of Shaker, Sharpkate, Sang, Jun, Y...
Fig. 7. Mediated multidrug resistance (MDR)-reversing effects of the compounds on doxorubicin (DOX)-...
Fig. 5. Experimental CD spectrum (red line) of compound 2, and the Rh2(OCOCF3)4 induced CD spectrum ...
Shaker, Sharpkate, Sang, Jun, Yan, Xue-Long, Fan, Run-Zhu, Tang, Gui-Hua, Xu, You-Kai, Yin, Sheng (2...
Fig. 1. The structures of compounds 1–30 and 8a.Published as part of Shaker, Sharpkate, Sang, Jun, Y...
Fig. 3. Key NOESY correlations () of compounds 1, 2, 4, 5, 6, and 8.Published as part of Shaker, Sha...
Fig. 6. Experimental ECD spectrum of 3 (red line) and calculated ECD spectra (200–400 nm) of (3S,4S,...
Fig. 4. Single-crystal X-ray structures of 1, 6, 7, and 8a.Published as part of Shaker, Sharpkate, S...
Fig. 10. Binding pose of 15 with human Pgp. The P-gp model was generated based on the PDB structure ...
Background: One of the most promising strategies to overcome multidrug resistance (MDR) is to use co...
Jatrophane diterpenes were shown to be inhibitors of P-glycoprotein (P-gp). There are also evidences...
Fig. 6. The inhibitory effects of diterpenoids 1–15 on HCE 2 (a). The inhibitory effects of diterpen...
Fig. 2. Key HMBC correlations of Compounds 1, 5 and 9.Published as part of Du, Kaicheng, Yang, Xinyo...
Fig. 5. Cytotoxic activities of transformed E. lathyris root extract in human carcinoma and embryoni...
Fig. 3. 1H–1H COSY and key HMBC (A) and ROESY (B) correlations of 3.Published as part of Wang, Siyi,...
Fig. 8. Effects of 15 on the expression of P-gp.Published as part of Shaker, Sharpkate, Sang, Jun, Y...
Fig. 7. Mediated multidrug resistance (MDR)-reversing effects of the compounds on doxorubicin (DOX)-...
Fig. 5. Experimental CD spectrum (red line) of compound 2, and the Rh2(OCOCF3)4 induced CD spectrum ...
Shaker, Sharpkate, Sang, Jun, Yan, Xue-Long, Fan, Run-Zhu, Tang, Gui-Hua, Xu, You-Kai, Yin, Sheng (2...
Fig. 1. The structures of compounds 1–30 and 8a.Published as part of Shaker, Sharpkate, Sang, Jun, Y...
Fig. 3. Key NOESY correlations () of compounds 1, 2, 4, 5, 6, and 8.Published as part of Shaker, Sha...
Fig. 6. Experimental ECD spectrum of 3 (red line) and calculated ECD spectra (200–400 nm) of (3S,4S,...
Fig. 4. Single-crystal X-ray structures of 1, 6, 7, and 8a.Published as part of Shaker, Sharpkate, S...
Fig. 10. Binding pose of 15 with human Pgp. The P-gp model was generated based on the PDB structure ...
Background: One of the most promising strategies to overcome multidrug resistance (MDR) is to use co...
Jatrophane diterpenes were shown to be inhibitors of P-glycoprotein (P-gp). There are also evidences...
Fig. 6. The inhibitory effects of diterpenoids 1–15 on HCE 2 (a). The inhibitory effects of diterpen...
Fig. 2. Key HMBC correlations of Compounds 1, 5 and 9.Published as part of Du, Kaicheng, Yang, Xinyo...
Fig. 5. Cytotoxic activities of transformed E. lathyris root extract in human carcinoma and embryoni...
Fig. 3. 1H–1H COSY and key HMBC (A) and ROESY (B) correlations of 3.Published as part of Wang, Siyi,...