Fig. 8. Effects of 15 on the expression of P-gp.Published as part of Shaker, Sharpkate, Sang, Jun, Yan, Xue-Long, Fan, Run-Zhu, Tang, Gui-Hua, Xu, You-Kai & Yin, Sheng, 2020, Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells, pp. 1-12 in Phytochemistry (112395) 176 on page 8, DOI: 10.1016/j.phytochem.2020.112395, http://zenodo.org/record/829566
Fig. 2. Key HMBC correlations of Compounds 1, 5 and 9.Published as part of Du, Kaicheng, Yang, Xinyo...
Fig. 3. Key NOE correlations of Compounds 1 and 5.Published as part of Du, Kaicheng, Yang, Xinyong, ...
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known t...
Fig. 9. (A) Inhibitory effects of 15 on the accumulation of rhodamin-123 (Rho-123) in HepG2/DOX. (B)...
Shaker, Sharpkate, Sang, Jun, Yan, Xue-Long, Fan, Run-Zhu, Tang, Gui-Hua, Xu, You-Kai, Yin, Sheng (2...
Fig. 1. The structures of compounds 1–30 and 8a.Published as part of Shaker, Sharpkate, Sang, Jun, Y...
Fig. 7. Mediated multidrug resistance (MDR)-reversing effects of the compounds on doxorubicin (DOX)-...
Fig. 3. Key NOESY correlations () of compounds 1, 2, 4, 5, 6, and 8.Published as part of Shaker, Sha...
Fig. 4. Single-crystal X-ray structures of 1, 6, 7, and 8a.Published as part of Shaker, Sharpkate, S...
Fig. 5. Experimental CD spectrum (red line) of compound 2, and the Rh2(OCOCF3)4 induced CD spectrum ...
Fig. 6. Experimental ECD spectrum of 3 (red line) and calculated ECD spectra (200–400 nm) of (3S,4S,...
Fig. 10. Binding pose of 15 with human Pgp. The P-gp model was generated based on the PDB structure ...
Background: One of the most promising strategies to overcome multidrug resistance (MDR) is to use co...
Jatrophane diterpenes were shown to be inhibitors of P-glycoprotein (P-gp). There are also evidences...
Du, Kaicheng, Yang, Xinyong, Li, Jiaheng, Meng, Dali (2020): Antiproliferative diterpenoids and acet...
Fig. 2. Key HMBC correlations of Compounds 1, 5 and 9.Published as part of Du, Kaicheng, Yang, Xinyo...
Fig. 3. Key NOE correlations of Compounds 1 and 5.Published as part of Du, Kaicheng, Yang, Xinyong, ...
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known t...
Fig. 9. (A) Inhibitory effects of 15 on the accumulation of rhodamin-123 (Rho-123) in HepG2/DOX. (B)...
Shaker, Sharpkate, Sang, Jun, Yan, Xue-Long, Fan, Run-Zhu, Tang, Gui-Hua, Xu, You-Kai, Yin, Sheng (2...
Fig. 1. The structures of compounds 1–30 and 8a.Published as part of Shaker, Sharpkate, Sang, Jun, Y...
Fig. 7. Mediated multidrug resistance (MDR)-reversing effects of the compounds on doxorubicin (DOX)-...
Fig. 3. Key NOESY correlations () of compounds 1, 2, 4, 5, 6, and 8.Published as part of Shaker, Sha...
Fig. 4. Single-crystal X-ray structures of 1, 6, 7, and 8a.Published as part of Shaker, Sharpkate, S...
Fig. 5. Experimental CD spectrum (red line) of compound 2, and the Rh2(OCOCF3)4 induced CD spectrum ...
Fig. 6. Experimental ECD spectrum of 3 (red line) and calculated ECD spectra (200–400 nm) of (3S,4S,...
Fig. 10. Binding pose of 15 with human Pgp. The P-gp model was generated based on the PDB structure ...
Background: One of the most promising strategies to overcome multidrug resistance (MDR) is to use co...
Jatrophane diterpenes were shown to be inhibitors of P-glycoprotein (P-gp). There are also evidences...
Du, Kaicheng, Yang, Xinyong, Li, Jiaheng, Meng, Dali (2020): Antiproliferative diterpenoids and acet...
Fig. 2. Key HMBC correlations of Compounds 1, 5 and 9.Published as part of Du, Kaicheng, Yang, Xinyo...
Fig. 3. Key NOE correlations of Compounds 1 and 5.Published as part of Du, Kaicheng, Yang, Xinyong, ...
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known t...