Possibilities of using intestinal microflora transplantation in the treatment of gastrointestinal diseases

Krawiec Karol, Sławiński Aleksander, Ryczkowski Aleksander, Neścior Małgorzata, Toruń Zuzanna, Orzeł Anna, Majchrzak Aleksandra, Piech Piotr. Possibilities of using intestinal microflora transplantation in the treatment of gastrointestinal diseases. Journal of Education, Health and Sport. 2018;8(9):926-932. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1418545 http://ojs.ukw.edu.pl/index.php/johs/article/view/5985 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.09.2018. Revised: 12.09.2018. Accepted: 12.09.2018. Possibilities of using intestinal microflora transplantation in the treatment of gastrointestinal diseases Karol Krawiec(1) , Aleksander Sławiński(1), Aleksander Ryczkowski(1), Małgorzata Neścior(1), Zuzanna Toruń(1), Anna Orzeł(1), Aleksandra Majchrzak(1), Piotr Piech (2) (1) Student’s Scientific Group at Department of Epidemiology and Clinical Research Methodology of Medical University of Lublin, Poland (2) Department of Human Anatomy, Medical University of Lublin, Poland Aleksander Sławiński: olek.slawinski@gmail.com Keywords: Clostridium difficile infections, Fecal microflora transplant, diarrhea ABSTRACT The number of Clostridium difficile infections (CDI) has significantly increased in Poland and throughout Europe. Their treatment involves the administration of metronidazole, vancomycin or fidaxomicin as indicated in current recommendations. Despite proper approach to the treatment, numerous recurrences of Clostridium difficile are reported. Fecal microflora transplant (FMT) is an alternative yet effective method of treatment of CDI. Moreover, this method is increasingly implemented in other disease entities. DESCRIPTION OF THE PROBLEM: Fecal microflora transplant (FMT) is a safe method of treating intestinal dysbiosis. The therapy is based on transferring the stool suspension from a healthy human (donor) to the patient (recipient). The transplant can be performed by oral route (through the gastric/duodenal probe) or via the rectal route (colonoscopy). The donor of the FMT material must give an informed consent to have performed numerous blood and stool tests that are included in the donor selection procedures. The day before transplant, the recipient has to take the last dose of vancomycin taken in the 14-day treatment