Study of Various Oxidants and Trace Elements in Cervical Cancer Patients at Tertiary Care Center of Udaipur, Rajasthan, India

Background: Cervical Cancer is one of the most common gynaecological malignancy worldwide. Approximately, 5,00,000 new cases are diagnosed every year with a higher rate of incidence among women of lower socioeconomic status especially in developing countries. Objectives: The objective of this study is to measure the oxidant status. To estimate and compare serum levels of oxidant MDA (malondialdehyde) and trace elements like Mg, Zn and their derangement in premenopausal and postmenopausal cervical cancer patients Methodology: These case control studies consist of 150 patients of cervical cancer along with 150 healthy subjects of précised matched age within the institution. blood samples was collected from all participants and samples were analysed for oxidant MDA (malondialdehyde)and trace elements like Mg and Zn. Results obtained were analyzed statistically to see the significance of differences. Results: The Mean concentration of S.MDA (nmol/L) in case group was 5.88 ±2.52 while that of cervical cancer, MDA, Mg, and Zn control group 2.92 ±0.70 and the difference among them found to be highly significant. Zinc and Magnesium levels were found to be low in cervical cancer patients as compared to control group. The Mean concentration of S. magnesium (mg/dL) was in case group was 1.30±0.44 and 1.91 ±0.29 control group and the difference among them found to be highly significant. Similar to that S. Zinc (mcg/dL) concentration in case group was 35.87 ±11.31 and in control group 118.26 ±29.41. And the difference among them found to be highly significant. Conclusion: We conclude that an imbalance between oxidant-antioxidant status of patients in case Group when compared to healthy controls. This imbalance plays an important role in the pathogenesis and progression of cervical cancer though the involvement of these parameters is altered in oxidative stress. The study found significantly lower concentrations of zinc and Magnesium in cervical cancer patients. Zinc and Magnesium supplements may therefore result in reduced cervical cancer occurrence among high risk women.http://impactfactor.org/PDF/IJCPR/14/IJCPR,Vol14,Issue4,Article3.pd