Genetic and Epigenetic Regulations of Tumor Progression and Metastasis

Cancer is a complex and heterogeneous disease that arises from the accumulation of genetic and epigenetic alterations in cells. Tumor progression and metastasis are the major contributors to cancer-related deaths worldwide. Understanding their underlying genetic and epigenetic mechanisms is essential for the development of effective diagnostic and therapeutic approaches. The aim of this reprint is to provide a wide range of topics, including the cellular and molecular mechanisms underlying tumor progression and metastasis, involvement of cell signaling pathways, cellular plasticity, and interactions with the tumor microenvironment. This reprint also discusses the role of oncogenes and tumor suppressor genes, chromosomal rearrangements, copy number variations, and epigenetic modifications. Furthermore, it provides the current state of the art in several aspects of cancer diagnosis, prevention, and treatment and highlights emerging therapeutic strategies based on genetic and epigenetic alterations. The contributing authors are renowned experts in the field of cancer research and treatment. They provide valuable insights into the latest discoveries and advances in cancer research and offer a unique perspective on the challenges and opportunities in the fight against cancer. We hope this reprint will serve as a valuable resource for researchers, clinicians, and students working in the field of cancer biology and oncology. We believe that the knowledge and insights presented here will inspire further research and innovation in the field of cancer research