ANALYSIS OF LEVEL OF ANTIOXIDANTS IN THE DIAGNOSIS OF HYPERTENSION IN PATIENTS

Introduction: Hypertension reigns as a leading cause of cardiovascular morbidity and mortality worldwide. Excessive reactive oxygen species (ROS) has emerged as a central common pathway by which disparate influences may induce and exacerbate hypertension. Objectives of the study: The basic aim of the study is to analyze the level of antioxidants in the diagnosis of hypertension in patients. Methodology of the study: This cross sectional study was conducted in Sargodha medical college, Sargodha during November 2018 to March 2019. The data was collected from 100 patients of both genders, age between 30 to 50years. 5cc blood was drawn from all patients for further analysis of antioxidants. Blood was centrifuged at 4000 rpm for 10 minutes and serum was separated. Blood samples were collected into EDTA tubes. Results: The data was collected from 100 patients. Level of antioxidants increases in hypertension patients due to increase in blood flow. The level of MDA, SOD, GSH and CAT vary in a different manner. The level of SOD become decreases due to hypertension. Antioxidants are compounds that are able to trap ROS and thus may be capable of reducing oxidative damage and possibly blood pressure. Conclusion: It is concluded that hypertension increased free radical levels in the blood. According to our study, levels of free radicals increase in the blood, which may stimulate antioxidant defense systems of body during hypertension