Relationships between parameters of uric acid exchange and immunity as well as microbiota in patients with neuroendocrine-immune complex dysfunction

Gozhenko Anatoliy I., Smagliy Vadym S., Korda Inna V., Badiuk Nataliya S., Zukow Walery, Kovbasnyuk Marta M., Popovych Igor L. Relationships between parameters of uric acid exchange and immunity as well as microbiota in patients with neuroendocrine-immune complex dysfunction. Journal of Education, Health and Sport. 2020;10(1):165-175. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.01.019 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.01.019 https://zenodo.org/record/3726839 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.12.2019. Revised: 25.12.2019. Accepted: 27.01.2020. RELATIONSHIPS BETWEEN PARAMETERS OF URIC ACID EXCHANGE AND IMMUNITY AS WELL AS MICROBIOTA IN PATIENTS WITH NEUROENDOCRINE-IMMUNE COMPLEX DYSFUNCTION Anatoliy I. Gozhenko1, Vadym S. Smagliy1, Inna V. Korda2, Nataliya S. Badiuk1, Walery Zukow3, Marta M. Kovbasnyuk4, Igor L. Popovych1,4 1Ukrainian Scientific Research Institute of Medicine for Transport, Odesa, Ukraine prof.gozhenko@gmail.com https://orcid.org/0000-0001-7413-4173 badiuk_ns@ukr.net https://orcid.org/0000-0002-8290-0605 2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine kordai@tdmu.edu.ua 3Nicolaus Copernicus University, Torun, Poland zukow@umk.pl https://orcid.org/0000-0002-7675-6117 4OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine i.popovych@biph.kiev.ua https://orcid.org/0000-0002-5664-5591 Abstract Background. Previously, we found a wide range of uric acid exchange parameters and functional relationships of uricemia and uricosuria with the parameters of immunity in healthy rats analyzed. The purpose of this study is to clarify such relationships in patients with neuroendocrine-immune complex dysfunction on the background of chronic pyelonephritis combined with cholecystitis in remission. Material and Methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets’ spa for the rehabilitation treatment. The serum and daily urine levels of the uric acid by uricase method were determined. Immune status evaluated on a set of I and II levels recommended by the WHO. The condition of microbiota is evaluated on the results of sowing of feces and urine. Results. The canonical correlation analysis revealed that raw uricemia determines by 28% nine parameters of immunity (relative blood content of pan-lymphocytes and their CD4+-, CD56+-, 0-populations, relative content of polymorphonuclear neutrophils, intensity and completeness of their phagocytosis Staph. aureus and their bactericidal capacity, saliva content of IgG) as well as bacteriuria and content in E. coli feces. Uricemia, normalized by sex and age, determines by 25% another constellation of immunity parameters (relative CD8+ lymphocytes content, CIC, E. coli phagocytosis intensity and completeness, Staph. aureus phagocytosis activity and completeness) as well as content in E. coli feces with impaired enzymatic activity and Klebsiela&Proteus. Instead, uricosuria determines only four parameters of immunity and only by 11,5%. Conclusion. Endogenous uric acid has a modulating overall beneficial effect on a number of immune and microbiota parameters in both healthy rats and people with neuroendocrine-immune complex dysfunction. Key words: Uricemia; Uricosuria; Immunity; Microbiota; Relationships; Humans