ANTI-TUBERCULOUS THERAPY INDUCED LIVER INJURY IN PULMONARY TUBERCULOSIS PATIENTS.

Objective: To assess the frequency of ATT induced hepatitis in pulmonary TB patients taking treatment. Materials and methods: This study follows cross sectional study design and was conducted at pulmonology department Mayo Hospital, Lahore. The study duration was from January to July 2018. Total 95 patients were enrolled and assessment of ATT induced hepatitis was made by recording data on a pre-designed Performa. Results: 37±14 years was mean age of patients. 53.7% were male and 46.3% were females. 36.8% patients suffered ATT induced hepatitis. 35.8% had raised AST. 35.8% had ALT raised while bilirubin level was higher in 36.8% patients. Conclusion: Frequency of patients suffering ATT induced hepatitis is found to be quite higher in this study. A significant number of patient suffered liver enzymes derangements as a result of anti-tuberculosis therapy. Key Words: Hepatitis, anti-tuberculosis, pulmonary tuberculosis, frequency