RISK FACTORS OF DRUG-INDECED HEPATITIS AMONG PATIENTS OF TUBERCULOSIS

Objectives: The aim of this research study is to diagnose various factors of risks of ATDH (Anti-TB Drug-induced Hepatitis) in the patients suffering from the disease of TB (Tuberculosis). Methodology: In this retroactive research work, we reviewed that clinical records of about four thousand diagnosed patients of TB in the Mayo Hospital Lahore. We also analyzed the data about the ATDH. The duration of this research was five years from May 2015 to April 2019. The patients of TB who were fulfilling the standard of NTP (National Tuberculosis Program) were the part of this research study. SPSS V.16 was in use for the statistical analysis of the research work. We also used Chi-square and Exact Fisher tests in this research work. Results: There were total 198 registered patients of ATDH during treatment and the follow up duration in which 32.80% (n: 65) were female & 67.20% (n: 133) were male patients with an average age of 43.20 years were the participants of this research work. There were statistically significant disparities between the infection of HIV and drug injections in vessels in the patients of ATDH & non-ATDH patients. Conclusion: All the past recognized risk factors for the incidence of ATDH, infection of HIV& IVDU were available with high significance. Key Words: Drug-Induced, Injections, Significance, Tuberculosis, Hepatitis Ethambutol, Incidence, Pyrazinamide