The process of cancer. Part III. Selected vitamins in cancer Chemoprevention

Jopkiewicz Sylwia. The process of cancer. Part III. Selected vitamins in cancer Chemoprevention. Journal of Education, Health and Sport. 2019;9(5):442-453. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3233449 http://ojs.ukw.edu.pl/index.php/johs/article/view/6953 https://pbn.nauka.gov.pl/sedno-webapp/works/914519 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.03.2019. Revised: 15.03.2019. Accepted: 28.05.2019. The process of cancer. Part III. Selected vitamins in cancer Chemoprevention Sylwia Jopkiewicz Orcid: http: /orcid.org/0000-0001-5453-4751 PhD student in the field of health sciences, Jan Kochanowski University, Faculty of Medicine and Health Sciences, ul. Ages IX Kielce 19, 25-317 Kielce. Address for correspondence: Sylwia Jopkiewicz, Jan Kochanowski University, Faculty of Medicine and Health Sciences, ul. IX Wieków Kielc 19, 25-317 Kielce; tel. 797 186-370, e-mail:Sylwia.Jopkiewicz@wp.pl. Summary: Introduction and objective: Free radicals (ROS), affect the course of each step of the process of carcinogenesis. Antioxidants that interact with ROS inactivates them, resulting in a positive effect both in preventing and inhibiting the progression of cancer. Vitamins such as A, C, E and D have anticancer properties. The article gives an overview of the problems of comp contribution of each vitamin in the chemoprevention of cancer. Its purpose is to present some antioxidants for its potential anti-tumor and to provide modifications to their effect on the carcinogenesis process. Description of knowledge: Vitamin A inhibits inter alia, lipid peroxidation and influences the growth and differentiation of epithelial cells to prevent neoplastic transformation. Vitamin E inhibits inter alia, angiogenesis, growth and proliferation of diseased cells. It also has the ability to stop the cell cycle. It prevents the formation of carcinogenic nitrosamines. Vitamin D inhibitor of vascular endothelial growth factor, and factors stimulating cell proliferation. Suppressive affects COX-2 enzyme. Increases the synthesis of E-cadherin. Vitamin C contributes to the proper functioning of the immune system by stimulating the activity of B and T lymphocytes is an electron donor for protecting cell components against oxidation. Stimulates cells to produce hyaluronidase inhibitor. Induces the synthesis of proteins p73 and MLH1. Conclusions: Imbalance redox system can lead to neoplastic transformation. Taking antioxidant supplements is associated with the risk of delivering them in too large a dose. Consequently, there is a support of the oxidation processes. The best way to protect against cancer and support cancer therapy is to provide antioxidants in their natural form, ie in the form of fresh vegetables and fruits. Keywords: antioxidants, carcinogenesis, vitamin