The process of cancer. Part II. Selected plant compounds in cancer. Chemoprevention

Jopkiewicz Sylwia. The process of cancer. Part II. Selected plant compounds in cancer. Chemoprevention. Journal of Education, Health and Sport. 2019;9(5):430-441. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3233443 http://ojs.ukw.edu.pl/index.php/johs/article/view/6949 https://pbn.nauka.gov.pl/sedno-webapp/works/914518 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.03.2019. Revised: 15.03.2019. Accepted: 28.05.2019. The process of cancer. Part II. Selected plant compounds in cancer. Chemoprevention Sylwia Jopkiewicz Orcid: http: /orcid.org/0000-0001-5453-4751 PhD student in the field of health sciences, Jan Kochanowski University, Faculty of Medicine and Health Sciences, ul. Ages IX Kielce 19, 25-317 Kielce. Address for correspondence:Sylvia Jopkiewicz, Jan Kochanowski University, Faculty of Medicine and Health Sciences, ul. IX Wieków Kielc 19, 25-317 Kielce; tel. 797 186-370, e-mail:Sylwia.Jopkiewicz@wp.pl. Summary: Introduction and objective: Constantly increasing number of cancers, as well as too low efficiency of the treatment of advanced stages of the disease implies the search for effective action both in terms of primary prevention and secondary. The article comp is only an outline of selected compounds share vegetable chemoprevention of cancer. Its aim is to introduce the concept of chemoprevention and discussion of selected plant compounds and their impact on the process of carcinogenesis. Description of knowledge: Method of connecting primary and secondary prevention is cancer chemoprevention. It uses natural and synthetic compounds to inhibit, delay or reverse the neoplastic process. Glucosinolates found in cruciferous vegetables have potent biological properties applicable to the prevention of the carcinogenesis process. The best-known glucosinolates are sulforaphane and indole -3-carbinol. Curcumin is a natural agent having a broad antitumor effect. It is among the blocking and suppressive chemopreventive agents. Inhibits activation of cancer gene, tumor growth, cell proliferation and angiogenesis. Resveratrol shows efficacy in blocking all stages of carcinogenesis, while lycopene is a powerful antioxidant, which inactivates free radicals thereby reducing the DNA damage of the cell. Conclusions: Chemoprevention is a method which may intervene in all stages of carcinogenesis, and the largest of its efficacy is observed in the initiation and promotion of cancer lesions. Some food ingredients have both a anticarcinogenic and cytostatic effects on cancer cells. Key words: Chemoprevention, glucosinolates, curcumin, resveratrol, lycopen