Supplementary Figure S4 from DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
- Bouchra Tawk (15389486)
- Katrin Rein (15389489)
- Christian Schwager (15389492)
- Maximilian Knoll (9526953)
- Ute Wirkner (15389495)
- Juliane Hörner-Rieber (15389498)
- Jakob Liermann (15389501)
- Ina Kurth (15098796)
- Panagiotis Balermpas (10517247)
- Claus Rödel (15389504)
- Annett Linge (15009665)
- Steffen Löck (15098784)
- Fabian Lohaus (15389507)
- Ingeborg Tinhofer (15389510)
- Mechtild Krause (15389513)
- Martin Stuschke (15389516)
- Anca Ligia Grosu (15389519)
- Daniel Zips (15389522)
- Stephanie E. Combs (15389525)
- Claus Belka (15389528)
- Albrecht Stenzinger (15389531)
- Christel Herold-Mende (15047946)
- Michael Baumann (15009662)
- Peter Schirmacher (15389534)
- Jürgen Debus (15389537)
- Amir Abdollahi (15026702)
Publication date
August 2023
DOIAbstract
Supplementary Figure 4 (Top). CD8 T cell enrichment is prognostic for Overall Survival (OS), local recurrence (LR) and disease progression but not for distant metastasis (DM) in HPV negative HNSCC in the DKTK-ROG cohort (n=88). (Bottom) After adjusting for Immune cell Infiltration, Hypoxia-M remained an independent prognosticator for local recurrence (HR=3.06, p<0.01) and for disease progression (HR=2.14, p<0.04) with a trend towards worsened OS (HR=1.92, p<0.09). CD8-IHC staining was an independent prognosticator for local recurrence (HR=0.41, p<0.03) an</p
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