HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation
- Linge, A.
- Lohaus, F.
- Löck, S.
- Nowak, A.
- Gudziol, V.
- Valentini, C.
- von Neubeck, C.
- Jütz, M.
- Tinhofer, I.
- Budach, V.
- Sak, A.
- Stuschke, M.
- Balermpas, P.
- Rödel, C.
- Grosu, A.-L.
- Abdollahi, A.
- Debus, J.
- Ganswindt, U.
- Belka, C.
- Pigorsch, S.
- Combs, S.E.
- Mönnich, D.
- Zips, D.
- Buchholz, F.
- Aust, D.E.
- Baretton, G.B.
- Thames, H.D.
- Dubrovska, A.
- Alsner, J.
- Overgaard, J.
- Krause, M.
- Baumann, M.
DOIAbstract
Objective To investigate the impact of the tumour volume, HPV status, cancer stem cell (CSC) marker expression and hypoxia gene signatures, as potential markers of radiobiological mechanisms of radioresistance, in a contemporary cohort of patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received primary radiochemotherapy (RCTx). Materials and Methods For 158 patients with locally advanced HNSCC of the oral cavity, oropharynx or hypopharynx who were treated at six DKTK partner sites, the impact of tumour volume, HPV DNA, p16 overexpression, p53 expression, CSC marker expression and hypoxia-associated gene signatures on outcome of primary RCTx was retrospectively analyzed. The primary endpoint of this study wa...
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