Areas with a strong industrial character are today in a phase of transition and transformation that must jointly address the regeneration of their heritage and the challenges of social inclusion and environmental sustainability. The methodological approach presented in the paper, which is the result of research and experimentation, is based on the actuation of multiple synergies: the integration between the different scales of the project that, starting from the comprehension of the context and its resources, leads to the development of regeneration strategies and the identification of the best re-uses; overcoming a sectoral approach towards innovative functional models for the public city by integrating technological and architectural reno...