The technologies that have been developed to address large-area and low-cost applications have been developed very recently and still pose severe limitations to the complexity achievable by integrated circuits. The transistor performance is limited and the process variations still represent a concrete issue with respect to circuit yield. In this chapter, the state of the art of large-area technologies is described, highlighting the main differences with respect to the most common standard silicon technologies. An overview is provided on the effort spent to build up a design flow platform easily configurable to address different and future technologies. The chapter concludes summarizing the state of the art in circuit design, which actually ...