The paper describes research activities of monitoring, modeling, and planning of people mobility in Rome during the Covid-19 epidemic period from March to June 2020. The results of data collection for different transport modes (walking, bicycle, car, and transit) are presented and analyzed. A specific focus is provided for the subway mass transit, where 1 m interpersonal distancing is required to prevent the risks for Covid-19 contagion together with the use of masks and gloves. A transport system model has been calibrated on the data collected during the lockdown period –when people's behavior significantly changed because of smart-working adoption and contagion fear– and was applied to predict future mobility scenarios under different ass...