National and international documents (UNESCO, 2017; MIUR, 2012; 2020) promote the improvement of the quality of teaching-learning processes, underlining the need to design flexibility learning environments able to respond to multiple educational needs. Physical education, like other disciplines, is involved in the process of full inclusion process with the awareness that in order to face to the complexity of the system (group-class), which in turn consists of a network of interconnected complex adaptive systems (pupils) – which acting and interacting with each other - a systemic approach is needed, able to of implementation of open and flexible teaching practices (Sibilio, 2014).This study aims to outline, in the light of recent neuroscient...