Population composition data and probabilistic representation.

(A) CIBERSORT deconvolution of TKO and RPM genetically engineered mouse model (GEMM) samples (previously published) as well as SCLC-A cell line samples. CIBERSORT was performed on bulk RNA-sequencing data. (B) Probabilistic representation of tumor proportion based on mean and standard deviation of proportions across samples within an experimental model; these distributions were then used for fitting models to data. TKO, p53fl/fl;Rbfl/fl;p130fl/fl tumors [28]; RPM, Rb1fl/fl;Trp53fl/fl;Lox-Stop-Lox[LSL]-MycT58A tumors [36]; SCLC-A cell lines, a subset of SCLC cell lines from the CCLE [54] that we previously assigned as representative of tumors made up largely of the SCLC-A subtype [33].