Comparative analysis of mouse models of lung cancer.

(A) Correlation matrix of log2 fold-changes (tumor vs normal) between the SPC-IGFIR model and mouse models of lung cancer. (B) Venn diagram and (C) scatterplot of log2 fold changes (tumor vs normal) between the SPC-IGFIR and C/L models. Only genes differentially expressed in the same direction in both the SPC-IGFIR models are plotted. (D) Dot plot of Areg and Ereg mRNA expression levels determined by qPCR (n = 5 for each group). Ereg, p Areg, p = 0.0004 by 2-tailed t-test. (E) Bar plot of Areg and Ereg log2 fold changes (tumor versus normal) derived from microarray datasets across multiple mouse models of lung cancer. Adenoma/adenocarcinoma (SI, SPC-IGFIR; C/L, CCSP-L858R; C/T, CCSP-T790M; C/L+T, CCSP-L858R+T790M, cR, cRaf1; M, SPC-Myc; U, Urethane; K, KrasLA2; S3, CCSP-Stat3C), Small cell lung cancer (RP, Rb/p53 DKO); Mucinous Adenocarcinoma (KN, KrasG12D/Nkx2.1+/-); Adenosquamous cell carcinoma (PS, Pten/Smad4 DKO); Squamous cell carcinoma (LP, Lkb1/Pten DKO).