Genomic inflation factors for epigenome-wide association studies on prevalent disease states.

Genetic and Environmental Factors Influencing the Genomic Prediction of Complex Traits

Nagpal, Sini

May 2022

Precision medicine is an emerging field in health care which aims to synthesize therapeutics precise...

Significant association of exposure-dependent changes in ECM gene sets from recent literature.

Michelle L. Engle (6411635)
Justine N. Monk (6411638)
Corey M. Jania (334464)
Jessica R. Martin (6411641)
John C. Gomez (6411644)
Hong Dang (2090011)
Joel S. Parker (109970)
Claire M. Doerschuk (2993703)

February 2019

Significant association of exposure-dependent changes in ECM gene sets from recent literature.</p

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

Evans, D.
Brion, M.
Paternoster, L.
Kemp, J.
McMahon, G.
Munafò, M.
Whitfield, J.
Medland, S.
Montgomery, G.
Timpson, N.
St Pourcain, B.
Lawlor, D.
Martin, N.
Dehghan, A.
Hirschhorn, J.
Davey Smith, G.
The GIANT consortium,
The CRP consortium,
The TAG Consortium,

January 2013

Author SummaryThe standard approach in genome-wide association studies is to analyse the relationshi...

Genomic inflation factors for epigenome-wide association studies on incident disease states.

Robert F. Hillary (7879010)
Daniel L. McCartney (8627955)
Hannah M. Smith (8531276)
Elena Bernabeu (16502957)
Danni A. Gadd (11958682)
Aleksandra D. Chybowska (16502960)
Yipeng Cheng (11521206)
Lee Murphy (274820)
Nicola Wrobel (2618077)
Archie Campbell (669891)
Rosie M. Walker (7879016)
Caroline Hayward (149856)
Kathryn L. Evans (7879013)
Andrew M. McIntosh (7879028)
Riccardo E. Marioni (6650288)

July 2023

Genomic inflation factors for epigenome-wide association studies on incident disease states.</p

Inflation factors in genomewide ovarian cancer association testing before (uncorrected) and after controlling for cumulative PCs from GWAS PCA, Paschou PCA, GWAS control PCA and GWAS LD PCA.

Paola Raska (165619)
Edwin Iversen (165624)
Ann Chen (84268)
Zhihua Chen (165630)
Brooke L. Fridley (93064)
Jennifer Permuth-Wey (165637)
Ya-Yu Tsai (73690)
Robert A. Vierkant (165641)
Ellen L. Goode (89912)
Harvey Risch (165647)
Joellen M. Schildkraut (165651)
Thomas A. Sellers (165654)
Jill Barnholtz-Sloan (125096)

May 2012

Inflation factors in genomewide ovarian cancer association testing before (uncorrected) and after...

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models - Fig 4

Jae Hoon Sul (421308)
Michael Bilow (2551291)
Wen-Yun Yang (652010)
Emrah Kostem (225206)
Nick Furlotte (2551294)
Dan He (145755)
Eleazar Eskin (108069)

March 2016

A distribution of inflation factors of GEI statistics on HMDP GxE GWAS data (A). HMDP cons...

Genomic inflation factors under polygenic inheritance

Yang, Jian
Weedon, Michael
Purcell, Shaun
Lettre, Guillaume
Estrada, Karol
Willer, Cristen
Smith, Albert
Ingelsson, Erik
O'Connell, Jeffrey
Mangino, Massimo
Nyholt, Dale
other, and

January 2011

Free to read full-text available via SharedIt link below Population structure, including population ...

Genomic inflation factors under polygenic inheritance.

Yang, J
Weedon, MN
Purcell, S
Lettre, G
Estrada, K
Willer, CJ
Smith, AV
Ingelsson, E
O'Connell, JR
Mangino, M
Mägi, R
Madden, PA
Heath, AC
Nyholt, DR
Martin, NG
Montgomery, GW
Frayling, TM
Hirschhorn, JN
McCarthy, MI
Goddard, ME
Visscher, PM

July 2011

Population structure, including population stratification and cryptic relatedness, can cause spuriou...

Significant associations from fully adjusted model—Epigenome-wide association studies on prevalent disease states.

Robert F. Hillary (7879010)
Daniel L. McCartney (8627955)
Hannah M. Smith (8531276)
Elena Bernabeu (16502957)
Danni A. Gadd (11958682)
Aleksandra D. Chybowska (16502960)
Yipeng Cheng (11521206)
Lee Murphy (274820)
Nicola Wrobel (2618077)
Archie Campbell (669891)
Rosie M. Walker (7879016)
Caroline Hayward (149856)
Kathryn L. Evans (7879013)
Andrew M. McIntosh (7879028)
Riccardo E. Marioni (6650288)

July 2023

Significant associations from fully adjusted model—Epigenome-wide association studies on prevalent d...

Disease gene groupings P-value distribution.

Nolan Priedigkeit (697703)
Nicholas Wolfe (697704)
Nathan L. Clark (509970)

February 2015

P-values represent the significance of elevated mean ERC within a particular disease. There is a ...

Genetic Factors Are Not the Major Causes of Chronic Diseases.

Stephen M Rappaport

January 2016

The risk of acquiring a chronic disease is influenced by a person's genetics (G) and exposures recei...

Genome-wide association study on physical activity based accelerated aging: negative log10 (p-value) vs. chromosomal position.

Alan Le Goallec (8822810)
Sasha Collin (14498442)
M’Hamed Jabri (14498445)
Samuel Diai (14498448)
Théo Vincent (14498451)
Chirag J. Patel (8822825)

January 2023

Dotted line denotes 5e-8. Genomic control inflation factor (lambda) was 1.04. 3 of the ten11 SNPs fo...

Causal Genomic and Epigenomic Network Analysis emerges as a New Generation of Genetic Studies of Complex Diseases

Momiao Xiong

August 2016

In the past decade, rapid advances in genomic technologies have dramatically changed the genetic stu...

Epigenome-wide association studies: potential insights into human disease

Bell, Christopher G.

August 2013

The burden on human health due to common diseases, such as the metabolic syndrome, cardiovascular an...

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Reshef, YA
Finucane, H
Kelley, DR
Gusev, A
Kotliar, D
Ulirsch, J
Hormozdiari, F
Nasser, J
O’Connor, L
van de Geijn, B
Loh, PR
Grossman, SR
Bhatia, G
Gazal, S
Pinello, L
Palamara, PF
Patterson, N
Adams, RP
Price, AL

January 2018

Biological interpretation of genome-wide association study data frequently involves assessing whethe...

Genetic and Environmental Factors Influencing the Genomic Prediction of Complex Traits

Nagpal, Sini

May 2022

Precision medicine is an emerging field in health care which aims to synthesize therapeutics precise...

Significant association of exposure-dependent changes in ECM gene sets from recent literature.

Michelle L. Engle (6411635)
Justine N. Monk (6411638)
Corey M. Jania (334464)
Jessica R. Martin (6411641)
John C. Gomez (6411644)
Hong Dang (2090011)
Joel S. Parker (109970)
Claire M. Doerschuk (2993703)

February 2019

Significant association of exposure-dependent changes in ECM gene sets from recent literature.</p

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

Evans, D.
Brion, M.
Paternoster, L.
Kemp, J.
McMahon, G.
Munafò, M.
Whitfield, J.
Medland, S.
Montgomery, G.
Timpson, N.
St Pourcain, B.
Lawlor, D.
Martin, N.
Dehghan, A.
Hirschhorn, J.
Davey Smith, G.
The GIANT consortium,
The CRP consortium,
The TAG Consortium,

January 2013

Author SummaryThe standard approach in genome-wide association studies is to analyse the relationshi...

Genomic inflation factors for epigenome-wide association studies on incident disease states.

Robert F. Hillary (7879010)
Daniel L. McCartney (8627955)
Hannah M. Smith (8531276)
Elena Bernabeu (16502957)
Danni A. Gadd (11958682)
Aleksandra D. Chybowska (16502960)
Yipeng Cheng (11521206)
Lee Murphy (274820)
Nicola Wrobel (2618077)
Archie Campbell (669891)
Rosie M. Walker (7879016)
Caroline Hayward (149856)
Kathryn L. Evans (7879013)
Andrew M. McIntosh (7879028)
Riccardo E. Marioni (6650288)

July 2023

Genomic inflation factors for epigenome-wide association studies on incident disease states.</p

Inflation factors in genomewide ovarian cancer association testing before (uncorrected) and after controlling for cumulative PCs from GWAS PCA, Paschou PCA, GWAS control PCA and GWAS LD PCA.

Paola Raska (165619)
Edwin Iversen (165624)
Ann Chen (84268)
Zhihua Chen (165630)
Brooke L. Fridley (93064)
Jennifer Permuth-Wey (165637)
Ya-Yu Tsai (73690)
Robert A. Vierkant (165641)
Ellen L. Goode (89912)
Harvey Risch (165647)
Joellen M. Schildkraut (165651)
Thomas A. Sellers (165654)
Jill Barnholtz-Sloan (125096)

May 2012

Inflation factors in genomewide ovarian cancer association testing before (uncorrected) and after...

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models - Fig 4

Jae Hoon Sul (421308)
Michael Bilow (2551291)
Wen-Yun Yang (652010)
Emrah Kostem (225206)
Nick Furlotte (2551294)
Dan He (145755)
Eleazar Eskin (108069)

March 2016

A distribution of inflation factors of GEI statistics on HMDP GxE GWAS data (A). HMDP cons...

Genomic inflation factors under polygenic inheritance

Yang, Jian
Weedon, Michael
Purcell, Shaun
Lettre, Guillaume
Estrada, Karol
Willer, Cristen
Smith, Albert
Ingelsson, Erik
O'Connell, Jeffrey
Mangino, Massimo
Nyholt, Dale
other, and

January 2011

Free to read full-text available via SharedIt link below Population structure, including population ...

Genomic inflation factors under polygenic inheritance.

Yang, J
Weedon, MN
Purcell, S
Lettre, G
Estrada, K
Willer, CJ
Smith, AV
Ingelsson, E
O'Connell, JR
Mangino, M
Mägi, R
Madden, PA
Heath, AC
Nyholt, DR
Martin, NG
Montgomery, GW
Frayling, TM
Hirschhorn, JN
McCarthy, MI
Goddard, ME
Visscher, PM

July 2011

Population structure, including population stratification and cryptic relatedness, can cause spuriou...

Significant associations from fully adjusted model—Epigenome-wide association studies on prevalent disease states.

Robert F. Hillary (7879010)
Daniel L. McCartney (8627955)
Hannah M. Smith (8531276)
Elena Bernabeu (16502957)
Danni A. Gadd (11958682)
Aleksandra D. Chybowska (16502960)
Yipeng Cheng (11521206)
Lee Murphy (274820)
Nicola Wrobel (2618077)
Archie Campbell (669891)
Rosie M. Walker (7879016)
Caroline Hayward (149856)
Kathryn L. Evans (7879013)
Andrew M. McIntosh (7879028)
Riccardo E. Marioni (6650288)

July 2023

Significant associations from fully adjusted model—Epigenome-wide association studies on prevalent d...

Disease gene groupings P-value distribution.

Nolan Priedigkeit (697703)
Nicholas Wolfe (697704)
Nathan L. Clark (509970)

February 2015

P-values represent the significance of elevated mean ERC within a particular disease. There is a ...

Genetic Factors Are Not the Major Causes of Chronic Diseases.

Stephen M Rappaport

January 2016

The risk of acquiring a chronic disease is influenced by a person's genetics (G) and exposures recei...

Genome-wide association study on physical activity based accelerated aging: negative log10 (p-value) vs. chromosomal position.

Alan Le Goallec (8822810)
Sasha Collin (14498442)
M’Hamed Jabri (14498445)
Samuel Diai (14498448)
Théo Vincent (14498451)
Chirag J. Patel (8822825)

January 2023

Dotted line denotes 5e-8. Genomic control inflation factor (lambda) was 1.04. 3 of the ten11 SNPs fo...

Causal Genomic and Epigenomic Network Analysis emerges as a New Generation of Genetic Studies of Complex Diseases

Momiao Xiong

August 2016

In the past decade, rapid advances in genomic technologies have dramatically changed the genetic stu...

Epigenome-wide association studies: potential insights into human disease

Bell, Christopher G.

August 2013

The burden on human health due to common diseases, such as the metabolic syndrome, cardiovascular an...

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Reshef, YA
Finucane, H
Kelley, DR
Gusev, A
Kotliar, D
Ulirsch, J
Hormozdiari, F
Nasser, J
O’Connor, L
van de Geijn, B
Loh, PR
Grossman, SR
Bhatia, G
Gazal, S
Pinello, L
Palamara, PF
Patterson, N
Adams, RP
Price, AL

January 2018

Biological interpretation of genome-wide association study data frequently involves assessing whethe...

Genetic and Environmental Factors Influencing the Genomic Prediction of Complex Traits

Nagpal, Sini

May 2022

Precision medicine is an emerging field in health care which aims to synthesize therapeutics precise...

Significant association of exposure-dependent changes in ECM gene sets from recent literature.

Michelle L. Engle (6411635)
Justine N. Monk (6411638)
Corey M. Jania (334464)
Jessica R. Martin (6411641)
John C. Gomez (6411644)
Hong Dang (2090011)
Joel S. Parker (109970)
Claire M. Doerschuk (2993703)

February 2019

Significant association of exposure-dependent changes in ECM gene sets from recent literature.</p

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

Evans, D.
Brion, M.
Paternoster, L.
Kemp, J.
McMahon, G.
Munafò, M.
Whitfield, J.
Medland, S.
Montgomery, G.
Timpson, N.
St Pourcain, B.
Lawlor, D.
Martin, N.
Dehghan, A.
Hirschhorn, J.
Davey Smith, G.
The GIANT consortium,
The CRP consortium,
The TAG Consortium,

January 2013

Author SummaryThe standard approach in genome-wide association studies is to analyse the relationshi...

Genomic inflation factors for epigenome-wide association studies on prevalent disease states.

Abstract

Extracted data

Genomic inflation factors for epigenome-wide association studies on prevalent disease states.

Abstract

Extracted data

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