The human skin is the outermost organ of the body. The thickness of the skin can give useful clinical information on its condition. In this thesis the complicated structure of the skin was described and methods of skin thickness measurement critically reviewed. Ultrasound was identified as a non-invasive method having several advantages over the other methods, such as safety, ease of use and low cost. The existing ultrasonic systems have not been successful to quantify the skin structure properly, due to lack of high resolution transducers and the biology of the skin structure. The PZFlex Finite Element Method (FEM) package was used to model the skin, an ultrasonic thickness measurement system, and their interaction, in order to define the ...