Novel therapeutic strategies to counter pseudomonas aeruginosa infections

Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsicmultidrug resistance and has a tremendous capacity to acquire further resistance mechanisms.During chronic infection, the bacterium can form a protective biofilm therefore reducing theefficacy of existing antibiotics. P. aeruginosa also harbors an impressive range of virulencefactors, many of which are controlled by the quorum-sensing system. Several novel therapeuticsare under investigation such as those directed against biofilm formation and quorum-sensingsystems along with bacteriophages and immunotherapies. Recent advances in next-generationsequencing and comparative genomics have opened the door to a new wave of smart drugdesign that could revolutionize P. aeruginosa treatment options