Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage
- Parry-Jones, Adrian R.
- Di Napoli, Mario
- Goldstein, Joshua N.
- Schreuder, Floris H. B. M.
- Tetri, Sami
- Tatlisumak, Turgut
- Yan, Bernard
- van Nieuwenhuizen, Koen M.
- Dequatre-Ponchelle, Nelly
- Lee-Archer, Matthew
- Horstmann, Solveig
- Wilson, Duncan
- Pomero, Fulvio
- Masotti, Luca
- Lerpiniere, Christine
- Godoy, Daniel Agustin
- Cohen, Abigail S.
- Houben, Rik
- Al-Shahi Salman, Rustam
- Pennati, Paolo
- Fenoglio, Luigi
- Werring, David
- Veltkamp, Roland
- Wood, Edith
- Dewey, Helen M.
- Cordonnier, Charlotte
- Klijn, Catharina J. M.
- Meligeni, Fabrizio
- Davis, Stephen M.
- Huhtakangas, Juha
- Staals, Julie
- Rosand, Jonathan
- Meretoja, Atte
Publication date
July 2015
DOIAbstract
Objective There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies. MethodsWe pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282), of whom 1,797 (17%) were on VKA. After excluding 250 patients with international normalized rati
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