Hemodynamic Effects of Levosimendan on Dexmedetomidine Infusion in Rats Under Isoflurane Anesthesia

Objective: In this study, hemodynamic effects of levosimendan (L) on dexmedetomidine (D) infusion in rats were investigated under isoflurane (I) anesthesia. Material and Methods: A total of eighteen female Wistar-Albino rats were divided into 3 groups. Rats were artificially respirated following cannulation and tracheostomy. At the end of the stabilization period (15 min), initial hemodynamic values were recorded and (i) 1(1.4%) was administered to Group I; (ii) 1(1.4%) and D (1 mu g/kg/dk) were administered to Group ID and (iii) 1 (1.4%), D (1 mu g/kg/dk) and L (0.3 mu g/kg/dk) were administered to Group IDL for 60 min. Heart rate (HR)(bpm), systolic (SAP), diastolic (DAP) and mean arterial pressure (MAP) (mmHg) were recorded with 5 min intervals were and given as mean and/or %. One way variance analysis, Tukey-Kramer and paired t tests were used, p<0.05 was considered the level of significance. Results: No difference was found between groups in terms of initial hemodynamic values. On the contrary, significant differences were found in HR (p=0.03) and DAP (p=0.03) at the end of the infusion period between groups. The differences were correlated to the lower HR in Group ID (176) compared to Group 1(237), (p<0.05) and a higher DAP in Group IDL (67) compared to Group 1(48), (p