Effect of short-term exposure to dichlorvos on rat hepatocyte: molecular and histopathological approach

Background: Organophosphate (OP) insecticides are the most widely used in both agricultural and landscape pest control. The mortality and morbidity rate of OP poisoning is high. The aim of the present study is to investigate the effect of acute organophosphate exposure on hepatocyte and to examine caspase 1 and caspase-3 gene expression, and cell apoptosis related genes as p53, Tumor Necrosis Factor-alpha, Hypoxia Inducible Factor 1-alpha expression changes in rat hepatocyte