Our chapter traces the origins of the psychoanalytic method back to experiences of non-ordinary states of consciousness achieved through the practice of hypnosis. Psychedelic medicines have the capacity to reveal hidden aspects of the unconscious mind that include symbolic elements and early organizational structures that correspond to Freud’s primary process thinking and which underpin conscious experience. These previously inaccessible layers comprise the building blocks of inner world formation, ideas about the self, and lenses, which serve to organize, construct and shape outer world experience. The chapter describes the signature features and experience of several popular psychedelic agents. Essential theoretical principles and process...