The male and female brains created by God are different. The existence of Islamic education specifically for men and women is a cultural construct. The existence of an attractive female-dominated teacher of Islamic Education Early Childhood (PIAUD) was investigated because it became a turning point in the formulation of gender studies between the emancipation of women and men. This study aims to explain the phenomenon of female teacher dominance in the perspective of gender and neuroscience. The research was conducted throughout 2017 at the TK Aisyiyah Nyai Ahmad Dahlan in Yogyakarta. This study used a qualitative approach, data collection techniques used observation, interviews, and documentation, while the triangulation analysis was car...