Objective: To compare the efficacy of trans-septal suturing with nasal packing following septoplasty in patients with the deviated nasal septum, in terms of frequency of postoperative pain, septal perforation, and synechiae formation. Materials and Methods: A randomized controlled trial was conducted in the ENT department of Benazir Bhutto Hospital Rawalpindi. Patients were divided into two groups. The total sample size of the study was 280 patients with 1:1 randomization in each group (140 in each group). Consecutive non-probability sampling was used for the recruitment of patients. All the patients underwent a septoplasty. Group A was provided with nasal packing while group B was with trans septal suturing. The study duration was 1 year (...