Local to global phenomena are omnipresent in mathematics, and since the appearance of the work of Grothendieck and his school it has been settled that the best way to treat such problems formally is via the theory of sheaves. It has been noticed already many years ago that sheaves are natural coefficients for cohomology theories defined on geometric objects of any kind, which means that they show their full power when set within a homotopical context. Therefore, one is somehow forced to move to the world of higher categories to work efficiently on the subject. This thesis essentially revolves around the theory of sheaves with values in infinity-categories, with a particular attention to its manifestations in topology and differential geomet...