Model for misfolded membrane protein-induced toxicity.
- Rachel Kandel (14493254)
- Jasmine Jung (14493257)
- Della Syau (14493260)
- Tiffany Kuo (14493263)
- Livia Songster (14493266)
- Casey Horn (14493269)
- Claire Chapman (14493272)
- Analine Aguayo (14493275)
- Sascha Duttke (3288519)
- Christopher Benner (193044)
- Sonya E. Neal (14493278)
Publication date
January 2023
DOI Publisher
Public Library of Science (PLoS)Abstract
A model depicting how accumulation of ER-resident misfolded membrane proteins would induce growth toxicity. (1) No growth toxicity is observed when misfolded membrane proteins aggregate but are not ubiquitinated. (2) No growth toxicity is observed when misfolded membrane proteins are ubiquitinated, but not aggregated. (3) Growth toxicity is observed when misfolded membrane proteins are both ubiquitinated and aggregated. ER, endoplasmic reticulum.</p
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