We describe the fifth edition of the CheckThat! lab, part of the 2022 Conference and Labs of the Evaluation Forum (CLEF). The lab evaluates technology supporting tasks related to factuality in multiple languages: Arabic, Bulgarian, Dutch, English, German, Spanish, and Turkish. Task 1 asks to identify relevant claims in tweets in terms of check-worthiness, verifiability, harmfullness, and attention-worthiness. Task 2 asks to detect previously fact-checked claims that could be relevant to fact-check a new claim. It targets both tweets and political debates/speeches. Task 3 asks to predict the veracity of the main claim in a news article. CheckThat! was the most popular lab at CLEF-2022 in terms of team registrations: 137 teams. More than one-...