15-3-7 :血管病変部を模擬する人工代替物を用いた血流 : 血管病変部間力学的相互作用の解明

Atherosclerosis is a common disease characterized by the Localized build-up of plaque within the intimal layer of an artery. As the disease progresses, stenosis is formulated. High grade stenoses can limit blood flow and produce conditions in which the artery may collapse. This resultant compression may be important in the development of atherosclerotic plaque fracture and subsequent thrombosis or distal embolization. We used experimental stenosis models with lipid core that closely approximate the arterial disease situation where the entire stenosis is compliant. We examined the influence of the presence of lipid core on pulsatile flow and deformation. We also aimed to develop the experimental model coronary stenosis. As the first step of development, the curved stenosis model was made. We examined the influence of curvature and stretch of the stenosis model on pulsatile flow and deformation.Article先進ファイバー工学研究教育拠点研究成果報告書 10: 74-75(2004)research repor