The energy requalification of the "Real Albergo dei Poveri", a monumental building in Naples, unique both for its shape and dimensions (about 103.000 m2) and for its architectural features and original functions is here presented.The procedure of analysis of the thermal behavior of the building and the proposals of sustainable interventions to obtain an energy efficient ancient building are presented. The goal is to achieve environmental comfort conditions and at the same time reduce energy consumptions by applying sustainable strategies regarding both the building envelope components, and also by an appropriate choice of the heating system. As it will be shown in the results of the analysis, the building is a massive structure and its wall...