Distribution of Neanderthal aSNPs identified within EUR across chromatin states and tissues.

Figure showing the patterns of enrichment across A) the 15 chromatin states for the entire set of Neanderthal aSNPs B) the 18 different tissues for the set of cis-regulatory Neanderthal variants segregating at common-to-high-frequencies in EUR. OR are computed relatively to the matched background set of naSNPs. Histograms on top indicate the mean number of variants annotated within each chromatin state (A) or within each tissue (B). The mean is respectively calculated across all 111 cell types and across the cell types belonging to each tissue. Asterisks indicate BH-corrected Fisher’s exact test p-values p ≤ 0.0001; *** = 0.0001 p ≤ 0.001; ** = 0.001 p ≤ 0.01; ** = 0.01 p ≤ 0.05. (PDF)