Cell type- and signaling pathway-specific changes in gene expression of SC specimens from control and CIE mice.

A, A multi-dimensional scaling plot of the SC samples shows group-specific clustering of the genes in the control (Ctrl) group, and in both experimental groups (CIE 1 wk, and CIE 4 wks). The coordinates on the axis are arbitrary. This plot is presented in a way of displaying similarities and differences between data points. Samples that are clustered together generally have similar patterns of expression. Gene changes in top 10 signaling pathways in the SC cord of CIE mice at 1 wk (B) and 4 wks (C) post-infection. D, Heat map of the genes clustered based on their expression levels in different cell types (SC specimens).