Impact of food pesticides on the gut microbiota

The Microbiome – New Addition to Our Tool Box Tuesday, May 24, 2016 11:30 Impact of Food Pesticides on the Gut Microbiota Rosita Gabbianelli1, Donatella Fedeli1, Laura Bordoni2, Dennis Fiorini3, Ivan Dus4, Cinzia Nasuti1 1 School of Pharmacy 2 School of Advanced Studies 3 School of Biosciences and Veterinary Medicine, University of Camerino, Italy 4 Head of Research for Chanson Water Company Taiwan The presence of pyrethroid pesticides in food is largely documented by many studies, which underline that dietary intake represents one of the main font of pyrethroid toxicity in humans. Their use is related to the protection of crops against pests in order to guarantee the increased request of food for people over the world. The relevant presence of pyrethroid metabolites in the urine of population confirms their presence in food, demonstrating that it is a global problem. Our previous studies demonstrated that exposure to permethrin, during early life, can modify Nurr1 gene expression and that the treatment with pesticide leads to a decrease of dopamine level in striatum of rats [1]. The damage could be counterbalanced by the co-treatment with protective bioactive compounds. Here we tested the effect of electrolyzed reduced water (ERW), prepared by using a Chanson Revolution 9 plates (Taiwan), in rats treated in early life with permethrin. Gut microbiota analysis and short chain fatty acids were analyzed. Results show a decreased Lachnospira strain in permethrin treated rats with respect to control ones, and the co-treatment with ERW increases this strain. Furthermore, an increase in Roseburia and Blautia was observed in co-treated rats. A positive effect of ERW was observed on fecal SCFA because butyric acid resulted significantly increased. The employ of ERW as functional water could be useful for health to counterbalance the damage due to pesticide intake through the food. [1] M. Carloni, C. Nasuti, D. Fedeli, M. Montani, M.S. Vadhana, A. Amici, R. Gabbianelli. Brain Res. 2013, 1515, 19