Steel frames with buckling-restrained braces (BRBs) have low lateral post-elastic stiffness, especially in the case of non-moment resisting beam-to-column connections, due to the brace limited post-yield stiffness. Thus, a tendency to soft storey formation, fostered by non homogeneous distributions of brace over-strength, might be observed during seismic events. The objective of this paper is to study the effects of brace over-strength distributions on the expected maximum reduction of seismic performance, as measured by local and global engineering demand parameters (EDPs). This goal is pursued using response sensitivity analysis and solving a constrained extreme problem. The general framework of the proposed sensitivity-based approach is ...