Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
- Fan Q
- Verhoeven VJ
- Wojciechowski R
- Barathi VA
- Hysi PG
- Guggenheim JA
- Höhn R
- Vitart V
- Khawaja AP
- Yamashiro K
- Hosseini SM
- Lehtimäki T
- Lu Y
- Haller T
- Xie J
- Delcourt C
- Pirastu M
- Wedenoja J
- Gharahkhani P
- Venturini C
- Miyake M
- Hewitt AW
- Guo X
- Mazur J
- Huffman JE
- Williams KM
- Polasek O
- Campbell H
- Rudan I
- Vatavuk Z
- Wilson JF
- Joshi PK
- McMahon G
- St Pourcain B
- Evans DM
- Simpson CL
- Schwantes-An TH
- Igo RP
- Mirshahi A
- Cougnard-Gregoire A
- Bellenguez C
- Blettner M
- Raitakari O
- Kähönen M
- Seppala I
- Zeller T
- Meitinger T
- Consortium for Refractive Error and Myopia
- Ried JS
- Gieger C
- Portas L
- van Leeuwen EM
- Amin N
- Uitterlinden AG
- Rivadeneira F
- Hofman A
- Vingerling JR
- Wang YX
- Wang X
- Tai-Hui Boh E
- Ikram MK
- Sabanayagam C
- Gupta P
- Tan V
- Zhou L
- Ho CE
- Lim W
- Beuerman RW
- Siantar R
- Tai ES
- Vithana E
- Mihailov E
- Khor CC
- Hayward C
- Luben RN
- Foster PJ
- Klein BE
- Klein R
- Wong HS
- Mitchell P
- Metspalu A
- Aung T
- Young TL
- He M
- Pärssinen O
- van Duijn CM
- Jin Wang J
- Williams C
- Jonas JB
- Teo YY
- Mackey DA
- Oexle K
- Yoshimura N
- Paterson AD
- Pfeiffer N
- Wong TY
- Baird PN
- Stambolian D
- Wilson JE
- Cheng CY
- Hammond CJ
- Klaver CC
- Saw SM
- Rahi JS
- Korobelnik JF
- Kemp JP
- Timpson NJ
- Smith GD
- Craig JE
- Burdon KP
- Fogarty RD
- Iyengar SK
- Chew E
- Janmahasatian S
- Martin NG
- MacGregor S
- Xu L
- Schache M
- Nangia V
- Panda-Jonas S
- Wright AF
- Fondran JR
- Lass JH
- Feng S
- Zhao JH
- Khaw KT
- Wareham NJ
- Rantanen T
- Kaprio J
- Pang CP
- Chen LJ
- Tam PO
- Jhanji V
- Young AL
- Döring A
- Raffel LJ
- Cotch MF
- Li X
- Yip SP
- Yap MK
- Biino G
- Vaccargiu S
- Fossarello M
- Fleck B
- Yazar S
- Tideman JW
- Tedja M
- Deangelis MM
- Morrison M
- Farrer L
- Zhou X
- Chen W
- Mizuki N
- Meguro A
- Mäkelä KM
DOIAbstract
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interaction...
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