Add to ORKGThe enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.Centro de Investigaciones Cardiovasculare
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
Previous work demonstrated that the slow force response (SFR) to stretch is due to the increase in c...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...
In this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stret...
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves ...
The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength...
Myocardial strain triggers an autocrine/paracrine mechanism known to participate in myocardial hyper...
The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength...
Myocardial stretch is a well-known stimulus that leads to hypertrophy. Little is known, however, abo...
Myocardial stretch induces a two-phase increase in developed force. The first phase occurs immediate...
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...
Background: The involvement of NHE-1 hyperactivity, critical for pathological cardiac hypertrophy (C...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
Previous work demonstrated that the slow force response (SFR) to stretch is due to the increase in c...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...
In this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stret...
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves ...
The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength...
Myocardial strain triggers an autocrine/paracrine mechanism known to participate in myocardial hyper...
The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength...
Myocardial stretch is a well-known stimulus that leads to hypertrophy. Little is known, however, abo...
Myocardial stretch induces a two-phase increase in developed force. The first phase occurs immediate...
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...
Background: The involvement of NHE-1 hyperactivity, critical for pathological cardiac hypertrophy (C...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
Previous work demonstrated that the slow force response (SFR) to stretch is due to the increase in c...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...