Add to ORKGIn this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy.We propose that the chain of events triggered by stretch begins with the release of small amounts of angiotensin II which in turn induce the release/formation of endothelin. The actions of these hormones trigger the production of mitochondrial reactive oxygen species that enhances NHE-1 activity, causing an increment in the intracellular Na+ concentration which promotes the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger. Thi...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
Myocardial stretch induces a two-phase increase in developed force. The first phase occurs immediate...
Myocardial stretch triggers an angiotensin II-dependent autocrine/paracrine loop of intracellular si...
The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered...
Myocardial strain triggers an autocrine/paracrine mechanism known to participate in myocardial hyper...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...
The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength...
The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength...
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves ...
When the length of the myocardium is increased, a biphasic response to stretch occurs involving an i...
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs...
Myocardial stretch is a well-known stimulus that leads to hypertrophy. Little is known, however, abo...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
Myocardial stretch induces a two-phase increase in developed force. The first phase occurs immediate...
Myocardial stretch triggers an angiotensin II-dependent autocrine/paracrine loop of intracellular si...
The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered...
Myocardial strain triggers an autocrine/paracrine mechanism known to participate in myocardial hyper...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...
The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength...
The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength...
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves ...
When the length of the myocardium is increased, a biphasic response to stretch occurs involving an i...
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs...
Myocardial stretch is a well-known stimulus that leads to hypertrophy. Little is known, however, abo...
Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which inclu...
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
This study was designed to gain additional insight into the mechanism of the slow force response (SF...
Myocardial stretch induces a two-phase increase in developed force. The first phase occurs immediate...
Myocardial stretch triggers an angiotensin II-dependent autocrine/paracrine loop of intracellular si...