A comparative analytical study of Ashodhit and Shodhit roots of Thevetia neriifolia Juss. W.S.R Yogratnakar

Background: In Ayurveda whenever poisonous drugs (Visha Dravya) used as a part of medicine, they need purification (Shodhana) before therapeutic use. Peet Karveer (Thevetia neriifolia Juss.) is a cardiac poison which contains mainly cardiac glycosides like Cerberin, Nerifolin, Thevetin A and B, Peruvoside, Ruvoside. If the toxic components are removed then Thevetia neriifolia Juss is a good source of medicine in many Ayurvedic formulations as an ingredient. Aim and Objectives: The aim of the present study was to compare various physicochemical parameters and HPLC analysis of Shodhit and Ashodhit Thevetia neriifolia Juss root with special reference to Yogratnakar. Material and Method: One part of Thevetia neriifolia Juss roots were pounded and made fine powder as Sample A and another part of Thevetia neriifolia Juss roots were subjected for boiling (Swedan) procedure in cow’s milk for 3 hours and made fine powder as Sample B. And studied the physicochemical and phytochemical analysis by HPLC. Result: After purification, different physicochemical parameters and phytochemical analysis which were performed using generally accepted laboratory technique, it was found that there was change in their values. Conclusion: The present study was reflected the importance of Shodhana (purification) method of the Thevetia neriifolia Juss roots (the toxic drug) which shows the reduction of toxic constituents.