We present taffo, a framework that automatically performs precision tuning to exploit the performance/accuracy trade-off. In order to avoid expensive dynamic analyses, taffo leverages programmer annotations which encapsulate domain knowledge about the conditions under which the software being optimized will run. As a result, taffo is easy to use and provides state-of-the-art optimization efficacy in a variety of hardware configurations and application domains. We provide guidelines for the effective exploitation of taffo by showing a typical example of usage on a simple application, achieving a speedup up to 60% at the price of an absolute error of 3.53×10−5. taffo is modular and based on the solid llvm technology, which allows extensibilit...