International audienceHelicases are ubiquitous molecular motor proteins that utilize the energy derived from the hydrolysis of nucleoside triphosphates (NTPs) to transiently convert the duplex form of nucleic acids to single-stranded intermediates for many biological processes. These enzymes play vital roles in nearly all aspects of nucleic acid metabolism, such as DNA repair and RNA splicing. Understanding helicase's functional roles requires methods to dissect the mechanisms of motor proteins at the molecular level. In the past three decades, there has been a large increase in the application of single-molecule approaches to investigate helicases. These techniques, such as optical tweezers and single-molecule fluorescence, offer capabilit...
Significance Bloom syndrome helicase (BLM) is a multifunctional helicase that primarily catalyzes th...
Bacteriophage T7 gp4 serves as a model protein for replicative helicases that couples deoxythymidine...
The maintenance of DNA integrity is a highly involved and regulated process, requiring the coordinat...
International audienceHelicases are ubiquitous molecular motor proteins that utilize the energy deri...
International audienceHelicases are ubiquitous molecular motor proteins that utilize the energy deri...
International audienceHelicases are ubiquitous molecular motor proteins that utilize the energy deri...
DNA helicases are motor proteins that catalyze the unwinding of double-stranded DNA into single-stra...
DNA helicases are motor proteins that catalyze the unwinding of double-stranded DNA into single-stra...
Almost all aspects of DNA metabolism involve separation of double-stranded DNA catalyzed by helicase...
Almost all aspects of DNA metabolism involve separation of double-stranded DNA catalyzed by helicase...
In the last 15 years, single molecule techniques have allowed us to observe the transient, heterogen...
Helicases are molecular motors that translocate along single-stranded DNA and unwind duplex DNA. The...
In the last 15 years, single molecule techniques have allowed us to observe the transient, heterogen...
Helicases are molecular motors that translocate along single-stranded DNA and unwind duplex DNA. The...
SummaryBacteriophage T7 gp4 serves as a model protein for replicative helicases that couples deoxyth...
Significance Bloom syndrome helicase (BLM) is a multifunctional helicase that primarily catalyzes th...
Bacteriophage T7 gp4 serves as a model protein for replicative helicases that couples deoxythymidine...
The maintenance of DNA integrity is a highly involved and regulated process, requiring the coordinat...
International audienceHelicases are ubiquitous molecular motor proteins that utilize the energy deri...
International audienceHelicases are ubiquitous molecular motor proteins that utilize the energy deri...
International audienceHelicases are ubiquitous molecular motor proteins that utilize the energy deri...
DNA helicases are motor proteins that catalyze the unwinding of double-stranded DNA into single-stra...
DNA helicases are motor proteins that catalyze the unwinding of double-stranded DNA into single-stra...
Almost all aspects of DNA metabolism involve separation of double-stranded DNA catalyzed by helicase...
Almost all aspects of DNA metabolism involve separation of double-stranded DNA catalyzed by helicase...
In the last 15 years, single molecule techniques have allowed us to observe the transient, heterogen...
Helicases are molecular motors that translocate along single-stranded DNA and unwind duplex DNA. The...
In the last 15 years, single molecule techniques have allowed us to observe the transient, heterogen...
Helicases are molecular motors that translocate along single-stranded DNA and unwind duplex DNA. The...
SummaryBacteriophage T7 gp4 serves as a model protein for replicative helicases that couples deoxyth...
Significance Bloom syndrome helicase (BLM) is a multifunctional helicase that primarily catalyzes th...
Bacteriophage T7 gp4 serves as a model protein for replicative helicases that couples deoxythymidine...
The maintenance of DNA integrity is a highly involved and regulated process, requiring the coordinat...