Background: We have recently shown that in MCD4 renal cells, cell surface AQP2 expression in cells exposed to CaSR agonists was higher than in control cells and did not increase significantly in response to short term exposure to forskolin. Those findings were in line with data obtained in hypercalciuric subjects displaying at baseline significantly higher AQP2 excretion and no significant increase in AQP2 excretion and urinary osmolarity after acute DDAVP administration compared to normocalciurics (Procino et al Plos One 2012). This indicates that CaSR-AQP2 interplay represents an internal renal defense to mitigate the effects of rising of calcium during antidiuresis on the risk of calcium precipitation. Methods: Human wild-type CaSR (hCa...
Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is express...
In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vas...
Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is express...
Background: We have recently shown that in MCD4 renal cells, cell surface AQP2 expression in cells e...
We previously described that high luminal Ca(2+) in the renal collecting duct attenuates short-term ...
We previously described that high luminal Ca2+ in the renal collecting duct attenuates short-term va...
Background: To evaluate some aspects of renal CaSR physiopathology, we analyzed the signaling underl...
Background: To evaluate some aspects of renal CaSR physiopathology, we analyzed the signaling underl...
Vasopressin (AVP) plays a major role in the regulation of water homeostasis by its antidiuretic acti...
One mechanism proposed for reducing the risk of calcium renal stones is activation of the calcium-se...
One mechanism proposed for reducing the risk of calcium renal stones is activation of the calcium-se...
Calcium (Ca2+) is a universal and vital intracellular messenger involved in a diverse range of cellu...
Calcium (Ca2+) is a universal and vital intracellular messenger involved in a diverse range of cellu...
One mechanism proposed for reducing the risk of calcium renal stones is activation of the calcium-se...
Disturbances in renal concentrating ability have been associated with hypercalciuria in humans and e...
Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is express...
In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vas...
Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is express...
Background: We have recently shown that in MCD4 renal cells, cell surface AQP2 expression in cells e...
We previously described that high luminal Ca(2+) in the renal collecting duct attenuates short-term ...
We previously described that high luminal Ca2+ in the renal collecting duct attenuates short-term va...
Background: To evaluate some aspects of renal CaSR physiopathology, we analyzed the signaling underl...
Background: To evaluate some aspects of renal CaSR physiopathology, we analyzed the signaling underl...
Vasopressin (AVP) plays a major role in the regulation of water homeostasis by its antidiuretic acti...
One mechanism proposed for reducing the risk of calcium renal stones is activation of the calcium-se...
One mechanism proposed for reducing the risk of calcium renal stones is activation of the calcium-se...
Calcium (Ca2+) is a universal and vital intracellular messenger involved in a diverse range of cellu...
Calcium (Ca2+) is a universal and vital intracellular messenger involved in a diverse range of cellu...
One mechanism proposed for reducing the risk of calcium renal stones is activation of the calcium-se...
Disturbances in renal concentrating ability have been associated with hypercalciuria in humans and e...
Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is express...
In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water transport by vas...
Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is express...