The paper presents the premises and some ongoing results from “Boa_Ma_Nhã, Maputo!”, a transdisciplinary research project based at Politecnico di Milano in partnership with Eduardo Mondlane University (Maputo, Mozambique) and the Italian Agency for Development Cooperation. The project is focused on the districts of Boane, Moamba, and Namaacha, questioning their role in consideration of the ongoing metropolisation of the Maputo Province, where the relation between urban and rural, national and transnational, local and global has become critical. Among the most pressing challenges, the main ones are related to the changing rural-urban socio-economic conditions and the local effects of climate change, including water comp...