Formulation and Evaluation of Ibuprofen Sustained Release Matrix Tablet

In present investigation an attempt has been made to design and develop Ibuprofen sustained release matrix tablets using HPMC K4M, K15M, and micro crystalline cellulose, as release retarding polymers. Ibuprofen is widely used as a centrally acting muscle relaxant; therefore have been selected to prepare sustained release dosage forms. The active pharmaceutical ingredient Ibuprofen was evaluated for its physical characteristics, analytical profiles and drug polymer compatibility study. The granules were prepared by wet granulation method. The prepared granules were evaluated for Angle of repose, Bulk density, Tapped density and Carr’s index. The results obtained were found to be satisfactory and within the specified limits. After compression parameters like Thickness, Hardness, Weight variation, Friability, and In-Vitro release studies were evaluated. In the present study the effect of types and concentration of polymer were studied on In-Vitro drug release. It shows that increase in concentration of polymer results in the sustained drug release for 24 hours. The study has revealed that by increasing concentration of polymer, release rate of drug was retarded and results confirmed that the release rate from hydrophilic matrix tablets depends on type and concentration of polymer. According to stability study it was found that there was no significant change in hardness, drug content and in vitro dissolution of optimized formulation (F5)